From Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim. The white numbers are the code numbers for the (unidentified) NMN and UA products purchased online and from pharmacies.
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Yes. Most NMN supplements are crap. The only one I trust is NMN from DoNotAge. It has been tested and found to be the real deal.
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I wish I could trust DNA. They seem sincere, work with Dr. Gorbunova, and make certificates of analysis available — but there’s information missing on their labels (including manufacturing dates) and they’re not enrolled in any independent quality monitoring program like USP, NSF, or ISO.
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Exactly! When it comes to supplements, stay with the ones that have in-house labs, and are tested by ConsumerLab.
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Well, then there’s the experiential aspect. When I take DNA NMN, I don’t get jetlagged when I travel. If I don’t take it, I waste 2 days in a jetlagged stupor. It’s probably the real deal.
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I wish the study “named and shamed” the ignoble suppliers of poor product! I guess they didn’t want the threat of litigation.
The fraudulence of the NMN suppliers, 87.5% of the list, far outweighed that of the UA suppliers (50%). UA is “relatively” easy to produce so there’s little reason to cheat the buyer.
This study is interestingly timed. I have just completed my own test of one Urolithin A supplier discused in this thread. I’m not sure if Aeternum were tested in the UA group, but by deduction they could be No2 in the graphic above.
I also found a well researched and written UA review and it included both Aeternum and Mitopure in their recommended products.
I am currently in the 2nd month of a planned 3 month Rapa holiday so I took the opportunity to do the UA test. I’ve now taken two doses of Aeternum UA, one week apart. The recommended dose is 500-1000mg, I took 500mg on each occasion. The result: very promising, I am usually as regular as clockwork with my morning constitutional visit. The day following my UA doses I had immensely satisfying and extended purges. I think this was gut mitophagy stimulated by the Urolithin A. I had no other side effects or sleep loss.
I have had a similarly rewarding purge response from Rapa but this mostly happened when I began Rapa a few years ago, or occasionally after a decent break. I presume that there is more material for autophagy to act upon ie damaged and nonfunctional cell parts, badly folded proteins, pathogens like viruses and bacteria, etc.
@John_Hemming has also tried the Aeternum product and he reported a sense that it had worked for him.
The fast witted among you will recognise the irony of my “purging” from the last word of the title of this thread. Ha!
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How am I supposed to know what this is? Can you please translate it and let us know what/how you felt. Thanks,
Sorry @SNK I thought this would be apparent, it is commonly used English term used when referring to bowel movements.
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Most supplement companies do not make their own base compounds. That is a very expensive and difficult business to get into and requires a high level of investment in equipment, facilities and people to produce quality base compounds.
Because of that, 90% of supplement companies do not “make” what they sell. Mine included. When you see “manufactured by” on a supplement label, all that claim requires is to put the raw materials in a cap, pill or gummie, and package it to use the “manufactured by” label. Which we, and many others do.
If you see “manufactured for” as you will often see in brands like Kirkland (costco) it is done in a white label facility that may (highly unlikely) or may not (the norm) make the base compounds. They manufacture to a specification and source the raw materials from dozens of companies that actually make the base compounds.
Fortunately my suppliers of base compounds are all top tier and their materials have all tested good.
It took me a while to sort through the dross to find companies I could trust like Sabinsa, Hygeia, Jiaherb and a few others. These companies supply many brands you may be familiar with.
And the companies that do manufacture the base compounds certainly can vary in quality.
The supplement supply chain is a very sophisticated and often complex system, from farmers of raw materials, like bark, fruits, etc. then to brokers of the raw materials, to the processors of those raw materials into base compounds, to bulk suppliers to small supplement companies to contract manufacturers, eventually to a brand and off to the consumer.
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Here is one of the top NMN manufacturers, they supply many of the good brands you may be aware of 
Well, if you truly believe Aeternum is a reliable brand, it does look like you can get it as 15, 30 and 100 gram bulk powder off Amazon. 100 grams is $200. At 0.5 grams/day dosing, that’s only $1 per day and would last you ~200 days.
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I checked their site out. They supply the NMN bulk to DoNotAge.Org
Which is endorsed by many of the YouTube gurus
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I thought amazon stopped selling it? Not seeing it anywhere on amazon? There is somethig called NMNH
but not NMN?
Please provide the link
I tried NMN from several suppliers. As far I could tell it did zilch for me,
no increased energy no obvious change in my blood markers.
I will give it a second try, but using NMNH, which is relatively new in animal and in vitro studies, it appears to be better than NMN. It certainly is cheaper, but the same problems apply to getting a brand that contains the dose on the label.
“Even at concentrations significantly lower than NMN, NMNH demonstrated a nearly 10-fold increase in cellular NAD+ levels, showcasing its remarkable efficacy.”
"Based on the available research, NMNH appears to be a more potent and effective NAD+ enhancer compared to NMN.
"Key Findings
Cellular NAD+ Levels
In vitro studies have shown that NMNH treatment (100 ÎĽM) increased cellular NAD+ levels by 5-7 folds in HepG2 cells, while the same concentration of NMN only slightly increased NAD+ levels.
Even at concentrations significantly lower than NMN, NMNH demonstrated a nearly 10-fold increase in cellular NAD+ levels, showcasing its remarkable efficacy.
Enzymatic Pathways
NMNH is the reduced form of NMN, and it appears to be more efficiently converted to NAD+ by the enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT).
Stability
NMNH is more stable than NMN under alkaline pH and low-temperature conditions.
However, NMNH is less stable than NMN at neutral pH in solution, with a half-life of approximately 2.4 days at room temperature and pH 7.0.
“NMNH increased the reduced NAD (NADH) levels in cells and in mouse livers. Metabolomic analysis revealed that NMNH inhibited glycolysis and the TCA cycle. In vitro experiments demonstrated that NMNH induced cell cycle arrest and suppressed cell growth.”
“Together, our data highlight NMNH as a new NAD+ precursor with therapeutic potential for acute kidney injury, confirm the existence of a novel pathway for the recycling of reduced NAD+ precursors and establish NMNH as a member of the new family of reduced NAD+ precursors.”
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Sorry but I was looking at the bulk Urolithin-A powder by Aeternum on Amazon, not NMN.
ah, got it. thanks,…
I do think they are a reliable brand.
I agree @desertshores although given the news that most NMN supplements don’t deliver the NMN as described, it’s hard be sure! I’ve discontinued all interest in NMN until there’s better supporting science that supplementation works.
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Thanks, great info and good to know.
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