@Agetron you still doing Doxycycline 200mg with your Rapa dose 100 day and 100 night or all together? I am going to do this too since I now have a bionic hip. Figure it should negate the risks of rogue bacteria inhabiting my prosthesis.
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Changes in Gut Microbiota Induced by Doxycycline …
by I Robles-Vera · 2021 · Cited by 6 — Doxycycline Treatment Improved Intestinal Integrity, Colonic Inflammation and Reduced Endotoxemia and Plasma Noradrenaline in DOCA-Salt Rats.
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Yes, I still take 200 mg on the day of my rapamycin dose.Yes, a 100 mg pill in morning and 100 mg at bedtime.
Pretty healthy… skin heals rapidly when injured. Open cut to gone in 5-7 days.
If you at this subclinical dose can see an increase in doxy-resistant bacteria and a decrease in friendly bífidus bacteria, I think it bodes bad for chronicle use at therapeutic dosage. It’s prescribed for youngster with severe Acne, but I don’t see it as proof for that it’s without side effects. Maximal treatment length against acne should be 3-4 months because the risk of developing resistente bacteria.
Doctors are probably prescribing doxy quite frivolously, because there already are a lot of of resistant bacteria circulating, knowing that they have heavier (as still effective broad spectrum) weapons in their arsenal.
I for sure know that i won’t volunteer to become a vessel for growing these resistente bacteria in my gut.
But each to their own. 
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I have been on the 6mg Rapa plus 100mg Doxcycline regime for about 4 months (almost immediately once I learnt about this).
The reason I was so quick to jump on this was twofold (I also have MS):
Synopsis: Addition of doxycycline to interferon-beta therapy in patients with relapsing-remitting multiple sclerosis might improve control of inflammatory lesions.
The rapamycin + doxycycline combination decreased tumour proliferation in about 2/3rd of the investigated cell lines. The continuous treatment reduced tumour growth significantly both in vivo and in vitro.
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I should have thought of this sooner. About a third of my femur plus my entire knee are mostly stainless steel (I had chondrosarcoma) and a big concern is infection which - if it gets to the implant - is Very Bad.
Thanks for the insight!
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Affordable Rifaximin/Rapamycin, Rybelsus,SIBO Discussions
Point by point analysis by Richard.
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It sounds like he’s dropped the doxycycline he was taking with rapamycin.
I also found this interesting:
And his current protocol:
Longevity Practices_27Nov23.pdf (658.2 KB)
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