They sell the NAD+ ( Nicotinamide Adenine Dinucleotide) injectable, needles for $350. Seems ripe for FDA cease and desist but thats another issue. Anyone have experience with this product? My wife has a few bad joints that this product may be of help. We are already keto, wear CGMs, fast, red light, PEMF. This might be a help.
I’ve been on rapa and the Johnson’esk kitchen sink for a few years, and doing ok.
It appears that NAD+ via IV is rapidly converted. I’m not convinced that IV application of NAD+ provides any better result than using a precursor like NR or NMN. I’m personally not interested in doing IV therapy that would be required for a lifetime to get a benefit.
I don’t see any studies on subcutaneous injection and I’m pretty sure? NAD+ orally has zero benefit due to the action of the digestive system.
A lifetime of taking an oral supplement is something I can tolerate.
A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+
In conclusion, this study was able to reveal for the first time some very useful, previously unknown, information about the fate of exogenous IV NAD+ in humans including, the overall safety and tolerability of an IV NAD+ infusion at a rate of 3 μmoles/min, the rapid sequestering of NAD+ from the plasma, the likely contribution of both NAD+ glycohydrolase and NAD+ pyrophosphate activity in the metabolism of NAD+ and the apparent efficient renal tubular reabsorption of NAM.
I’ve been taking NMN for NAD boosting. It helps with jet lag (I don’t get jetlagged when I take NMN) and an energy boost (placebo?). Due to its effects on jet lag, I know it is doing something. Whether it is going to improve my lifespan is another question. There are many other things that I feel are more useful. NMN is just useful enough that I haven’t dropped it yet.
