Does high LDL cholesterol help make microplastics (often fat-soluble) more easily absorbed?

Microplastics are detected in human gallstones and have the ability to form large cholesterol-microplastic heteroaggregates

Highlights

  • Microplastic were present in gallstones, with significantly higher levels observed in younger cholelithiasis patients.

  • Microplastic ingestion accelerated the formation of gallstone in mice.

  • Microplastics exhibited strong affinity for cholesterol and formed cholesterol-microplastic heteroaggregates.

  • Microplastic ingestion altered the composition of the gut microbiota in mice fed a high-cholesterol diet.

https://www.sciencedirect.com/science/article/abs/pii/S0304389424002103