https://ascopubs.org/doi/abs/10.1200/JCO.2024.42.16_suppl.e14562
In this double-blind, prospective, placebo-controlled trial (NCT05735886) we sought to characterize for the first time the effects of UA on the human immune system. Fifty healthy participants aged 45-70 years were randomized (1:1) to an intervention of single-dose (1000mg) UA or placebo per day for a study duration of 28 days. Randomization was performed based on age, gender and BMI. Exclusion criteria were prior medical conditions, BMI >35 kg/m2, smoking, and intake of prescription medication or other dietary supplements. The primary end points of the study were changes in peripheral CD3+ cells, as well as alterations in mitochondrial activity in select immune populations of the peripheral blood as assessed by flow cytometry. Results: Intake of UA was safe and well-tolerated in the intervention cohort of 25 participants. After the study period, total peripheral lymphocytes and circulating NK cells were expanded in the UA group. Performing a complete immunophenotyping via spectral flow cytometry, we found that UA elicits immune remodeling characterized by broad changes of immune surface markers and mitochondrial measurements. CD8+ cells of participants in the intervention arm displayed greater mitochondrial mass, while preferably taking on a naive phenotype and expressing more Ki67. In addition, circulating monocytes exhibited a less inflammatory signature. UA intake reduced plasma levels of several proinflammatory cytokines. Conclusions: Collectively, our study constitutes an unprecedented intervention-based assessment of immune aging that globally characterizes the effect of UA on the immune system, proposing validation in future confirmatory studies and potential combination with cancer immunotherapy.
Interesting, thank you for bringing my attention to this report. I have been adding a small amount of 40% ellagitannins in the form of pomegranate extract to my yogurt smoothies a few times a week for a few years, letting the gut microbiome do their thing to hydrolyze and convert it to urolithins. This and other literature supports it might be helpful for long term immunological health.
Under what rock did they find 70yo taking no medications or supplements?
And a BMI <35 is “healthy”?
“According to the World Health Organization (WHO), a body mass index (BMI) of 30 or higher is considered obese.”
It is a study driven by Amazentis SA, a biotech company behind Nestlé (commercializing urolithin A). This explains why the study positions itself as an ‘unprecedented intervention-based assessment.’ 
So, it’s good to know, but I would take the results with a grain of salt.
I’m looking forward to see if UA, as part of my Super Mix, has any effect on my next Trudiagnostic test in September.
I will be posting that.
In the mean time I need to post my disappointing SYMPHONYAge results and my wifes spectacular results.
The sponsor may have been Amazentis but it is still a double-blind, placebo-controlled clinical trial and the Journal of Clinical Oncology is pretty highly ranked. Sure…be a little skeptical but I would take it is more promising signs of Urolithin A being good for us, whether supplementing it or natural intake via walnuts and the like.