Its probably a cost thing.
2 Likes
They do store tissue samples. Other people could do the biomarker studies. Perhaps no one cares about mouse biomarkers.
Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let’s talk about sex
Data demonstrated that age induced skeletal muscle atrophy and fibrosis in both sexes. In females, however, this adverse skeletal muscle remodeling was more accentuated than in males and might be attributed to an age-related reduction of 17beta-estradiol signaling through its estrogen receptor alpha located in mitochondria. The females-specific mitochondrial remodeling encompassed increased abundance of proteins involved in fatty acid oxidation, decreased abundance of the complexes subunits, and enhanced proneness to oxidative posttranslational modifications. This conceivable accretion of damaged mitochondria in old females might be ascribed to low levels of Parkin, a key mediator of mitophagy. Despite skeletal muscle atrophy and fibrosis, males maintained their testosterone levels throughout aging, as well as their androgen receptor content, and the age-induced mitochondrial remodeling was limited to increased abundance of pyruvate dehydrogenase E1 component subunit beta and electron transfer flavoprotein subunit beta. Herein, for the first time, it was demonstrated that age affects more severely the skeletal muscle mitochondrial proteome of females, reinforcing the necessity of sex-personalized approaches towards sarcopenia management, and the inevitability of the assessment of mitochondrion-related therapeutics.
Open access paper:
https://www.sciencedirect.com/science/article/pii/S0891584924001709
2 Likes
That’s interesting. It’s well understood that male testosterone does drop during aging but perhaps that is an effect independent of “aging” but related to something like an accumulation of bad habits which drive testosterone down. Alcohol. Sedentary lifestyles. Poor sleep. Being a Miami Dolphin fan (they always lose).
5 Likes
4 Likes
I listened to the interview. It’s really interesting. I hope they can find the funding. Just taking a bit of a step back. It’s heartening to see companies and individuals pushing to get these therapies into humans.
3 Likes