Rapamycin etc., Purchase Price Comparison Spreadsheet, and Issues Discussion

FWIW

Received a marketing email today 04/05/2024

“50 x 1mg Film Coated Rapamycin (Sirolimus nanoparticles) Tablets”

RapaPro brand, manufacturer in India.

$70.00

I do not have any financial interest in this organization.

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I’ve just discovered that CVS is now offering Sirolimus for a little over $1 per mg, via GoodRx coupon. This is 1/5 the price they were in Dec 2021, and 1/3 of the Kroger’s price then and now. To me this is big news- means I can buy from US pharmacies rather than using the India crap-shoot route (just got another India order returned by Canada Customs).

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Who are you getting your prescription from and does it contain refill options?

Dr Alan Green, and yes.

He’s great. In-person visit required initially (Little Neck, NY on Long Island), but subsequent consultations can be on Zoom. Very reasonable cost.

It’s a good idea to be under some kind of supervision by a doctor, and Dr Green is pretty much the world expert, with over 1500 patients now. He requires blood tests prior to your visit, which makes sense. He is thorough.

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Even cheaper with larger quantities. With these prices, India no longer makes sense.

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In the North New Jersey area on 04/13/2024
GoodRx produced a discount code for generic rapamycin/sirolimus 180 X 1mg tables for $111.00 paying out of pocket with discount code

Less than .62¢ per mg

Yes, you would require a prescription.

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India still makes sense if you need to get other, still expensive medications such as an SGLT2I or Bempedoic Acid.

However it’s great to have a local source for Sirolimus. Thanks for sharing.

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TOO GOOD TO BE TRUE???

I went to Goodrx and with their coupon it says I can buy 180 pills at CVS for $110.
They sent the coupon to my mailbox.
The other pharmacies were much more, even if not crazy.

Am I missing something ??? I’ve never used good rx. I assume it’s just a first time user coupon/promo?

Do I need to make sure CVS uses a good quality generic sourced from the right place?

Or do I just not look a gift horse in the mouth?

THANK YOU!!

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No - anyone can create a GoodRX account, and you get a GoodRX number that you present when you buy at one of the pharmacies, and you get the discount. Its easy.

Any generic from a regular pharmacy like CVS, Walgreens, etc. is fine. Its the compounding pharmacy products you want to be careful with and which have a history of not being very bioavailable.

https://www.goodrx.com

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Wow, grateful for your list of where to buy! I bought my first 24 pills for $239! You’ve saved me a fortune! Thx!

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Prices from Forveda as of May:
Siromus 1mg by Zydus @ 5.5 USD per strip (6 tablets)
Rapacan (Siromus 1mg) by Biocon @ 5 USD per strip (10 tablets)
Bempedoic acid (180mg) + Ezetimibe (10mg) tablets costing
135 USD for 20 strips (200 tablets) and
240 USD for 40 strips (400 tablets).
Metformin 1 gm SR @ 1 USD per strip (10 tablets)
Glucobay 50 mg @ 2.5 USD per strip (10 tablets)

EMS Shipping charges 40 USD for up to 400 tablets are high, but Forveda has a virtual US bank so the ACH transfer fees are free for most US banks.

I’ve been messaging Girish Bhattad via IndiaMart, and he’s quick to reply. I placed my first order in early April and although he shipped within 2 days of payment, it took 4 weeks to be delivered to the US.

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I wrote to him a week ago, no response (yet). It’s a 5-hour drive for me, but I’d do it. Fascinating fellow, my first response was: “Uh, you don’t look so good…” But then I understood that normally he’d be dead from a rare genetic cardiac issue that killed two others in his family." What’d he cost, if you are willing to say?

It’s $400 for the initial visit now- was $300ish in 2021.

It was an 8 hour drive for me, plus a border crossing, plus Covid testing to get back across, back then. Definitely worth it. Got me started, and I’ve had a follow-up Zoom since, which costs less.

On his web site, search for “Office Protocol”. It’s about a third of the way down the site, which is many screens down, at it has details.

He does say: “ The office runs on E-mails. Telephone calls are scheduled. I don’t do cold calls.**

To schedule an appointment, send an email. I see patients every weekday, 11 a.m. to evening as needed.

**I have far more time to respond to emails on Saturday and Sunday. These are the best days to send E-mails and if I failed to respond to your E-mail, the same day you sent it; please resend it on Saturday or Sunday and note that follow-up E-mail.”

So send an email today, (Sunday), you should get a reply.

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I checked locally today on prices, wow! He’s worth tying up with just to be able to buy locally…

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Very positive feedback from dealing with RL Pharma in India. You will use WeChat for communication. I specified Zydus sirolimus . Cost was $200 for
150 1mg tabs.
Their price for The best Metformin, Glucomage 1000mg, SR , was a super cheap $17 for 210 tabs. !
Shipping for both was the same as just Sirolimus at $40.
Package was tracked, EMS, arrived in 2 weeks.
My only issue was not them but my bank raped me for $50 for International Wire Transfer.
In my communications via WeChat, I had to keep reminding them I wanted highest quality, not lowest price. I specified Zydus and ask for manufacturers Reputation on the Metformin supplier.

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I’ll second him. I did use Wise to transfer $, which, I think ended costing about $10 much less than $50 wire transfer. I think it was $1.50/mg Zydus.

Latest purchase from Jagdish.

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Here is a recent cost estimate of some medicines of interest from Jagdish of RL Pharma. I expect the prices will go down a little when ordering in quantity. I’m tempted by the 3 mg siroboon since it means taking fewer pills and it’s less expensive, but based on comments in this thread, I’ll probably go with rapacan, which is produced by Biocon, whose quality control I know to be solid.

Any thoughts?

1- Glucobay 25 Tablet , Acarbose 25mg = 1.2 USD for 10 Tablets.
2- Glucobay 50 Tablet , Acarbose 50mg = 2.4 USD for 10 Tablets.

3- Brillo EZ 180mg/10mg Tablet , Bempedoic acid (180mg) + Ezetimibe (10mg) = 5 USD For 10 Tablets.

4- Invokana 100mg Tablet , Canagliflozin (100mg) , Johnson & Johnson Ltd = 7.5 USD for 10 tablets.

5- Jardiance 10mg Tablet; Empagliflozin (10mg) = 7.2 USD for 10 tablets
6- Jardiance 25mg Tablet;Empagliflozin (25mg) = 8.8 USD for 10 tablets.

7-Rapacan 1mg Tablet ; Sirolimus (1mg) ; Eris = 6.5 USD for 10 Tablets.
8- Siroboon 1mg Tablet ; Sirolimus (1mg) = 5 USD for 10 Tablets.
9-Siroboon 2mg Tablet ; Sirolimus (2mg) = 8 USD for 10 Tablets.
10- Siroboon 3mg Tablet ; Sirolimus (3mg) = 11 USD for 10 Tablets

Hi, just wanted to add some information about the rapamycin supplier G.P. Pharma in India. I just ordered the second batch of 100, 1mg rapacan tablets, manufactured by Biocon. Total cost was $125USD. I ordered this on 6/15/2024 and it was delivered by USPS to my residence on 7/5/2024.
There was a couple, few days of them not replying to my request for tracking#, after ordering and knowing they received my payment. But they updated me eventually.
They use an India Post tracking number, that is transferred to a USPS tracking number after ariing and going through US customs.
As with the first batch, this will last me about a year, as i take 2, 1mg tablets roughly once a week with a small 6 or 8 ounce cup of grapefruit juice.
Pics of front and back labels of package that arrived are included. Package was carboard box wrapped in heavy, blue paper with lables taped to the box, as was the first package over a year ago.


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