Any idea if taking Artichoke extract and Milk Thistle to prevent raised ALT and AST levels from all the medications I take, can interact with Rapamycin absorption?
Also just to be safe I do not take Citrus Bergamot 24hrs before or after my Rapa dosage as it has grapefruit like qualities which can inhibit some CYP enzymes, albeit pretty weakly.
No - Sorry, I’ve not looked into this issue at all.
If anyone is on a liver cleanse with Milk thistle, please keep in mind that :
" Taking milk thistle might decrease how well the liver breaks down sirolimus. This might increase the effects and side effects of sirolimus."
I don’t have time to look into this in any detail, but this quote suggests that milk thistle won’t reach high enough concentrations to influence rapamycin metabolism in humans unless perhaps in those that suffer from liver damage:
" Both SLM and GLZ formulations, taken by a relatively large number of patients (15 and 19, respectively), were shown to reduce sirolimus CL/F significantly by about 34%. Silymarin, a flavonolignan from the ‘milk thistle’ plant, has been used almost exclusively for hepatoprotection for hundreds of years all over the world [56]. It is a complex mixture of four flavonolignan isomers, namely silybin, isosilybin, silydianin and silychristin [56]. In vitro studies have shown that silymarin, in higher concentrations, has a strong inhibitory effect on both P450 3A4 [56–58] and P-gp [59–61]. The concentration tested in vitro exceeded physiologically attainable levels [56–58, 60, 61] and hence previous studies in vivo have shown no to mild inhibition effects when co-administered with ranitidine [62], nifedipine [63], midazolam [64] and indinavir [65, 66] in healthy volunteers. Recently, Schrieber et al. reported that AUC0–24 h for the sum of total silymarin flavonolignans was 2.4-, 3.3- and 4.7-fold higher for hepatitis C virus (HCV) noncirrhosis, non-alcoholic fatty liver disease, and HCV cirrhosis cohorts, respectively, compared with healthy volunteers [67]. It is a common practice in China as well as in the current study that SLM or GLZ is added by clinicians when patients have abnormal liver function indices. Therefore, the remarkable inhibition effect of SLM on sirolimus CL/F could be explained by accumulated high concentrations of SLM in these patients with hepatic impairment."
Quote is from here: Population pharmacokinetics of sirolimus in de novo Chinese adult renal transplant patients - PubMed
Hi
I get my testing done in the UK at the Nuffield ( Labs) with my blood draw at the Chandlers Ford Hospital - all very relaxed - results by email with 48hrs - £50 last time around - do it once a year - get confused by units - State side are different to here but can convert between
I arrange it direct with the labs and am happy to share a prior email to give contact details
Hi
How do you reply to a specific individual posing a question?
Thanks
hit the reply button in the lower right hand part of their post. It’s not blue.