My recollection on the studies was an association of patients with more Rxs filled for PDE5-i’s, the lower the incident cases of AD. I’d presume most of the Rx’s were for ED, probably less for BPH and less further for pulmonary hypertension.
Looking at the mechanism, I’d think probably think a continuous level would likely generate the most benefit.
We have Sildenafil (Viagra) T 1/2 is 4 hrs, Vardenafil (Levitra) T 1/2 is 6 hrs, Tadalafil (Cialis) T 1/2 is 15-35 hrs for high doses - but for daily use 17.5 hrs, and Avanafil (Stendra) T 1/2 is 3-4 hrs
All of this is speculative, but if no contraindication tadalafil would seem the winner due to long half life and low cost. I suspect just usual standard daily dose would be the approach.
It’s been my approach in this space, but it’s an area without definitive evidence - however the risk/benefit would seem to favor this for a lot of people. I don’t know the age - I know Dr. Green with Rapamycin feels high risk should start at age 35 yrs, and moderate risk (e.g. Apo E3/E4) at age 40. Even with the low risk ApoE2/E2, if you live long enough still have significant incidence of dementia. We however don’t know if these are all the same mechanism, and whether these agents work for any/all of them.
This is just my general approach and rationale. Obviously not personal medical advice… but worth discussing with your physician.
To move back to the topic of this thread … and ask something that has been asked umteen times before:
All the studies point to sildenafil being protective against AD, but where is the evidence that ALL the PDE5i’s are equally effective? In particular what about tadalafil?
We would also expect it to be mechanism of action … not the actual structure of one vs another and this study suggests that. It would logically extend having a form with a long half life would expect to have the most benefit.
There isn’t a good trial showing this definitively, but the group of studied in my reading has me looking at a sustained serum level as likely to yield highest benefit.
Ever use of marijuana and each additional marijuana-year were associated with a 6-month (P < 0.001) and a 2.5-month (P < 0.001) higher average in GrimAge acceleration (GAA) using generalized estimating equations, respectively. Recent use and each additional day of recent use were associated with a 20-month (P < 0.001) and a 1-month (P < 0.001) higher GAA, respectively.
I tend to agree. I experienced no positive effects other than falling asleep. actually, it was very inflammatory in my case, that is why I wasn’t a fan of recreational use, and never used as such. I also thought that its use made one easier to forget things (forget to do something you were planning on doing). However, it did definitely have a significant calming effect which always resulted in making me fall asleep (if I were having difficulty sleeping).
I have to say, I can only tolerate 2.5mg cialis per day. Otherwise I get a stuffy nose, acid reflux, and red eyes. I’ll take more if necessary for sexual reasons but if we leave that aside, 2.5mg is I can handle before side effects get to me.
Association of Cannabis Use With Cardiovascular Outcomes Among US Adults
Conclusions
Cannabis use is associated with adverse cardiovascular outcomes, with heavier use (more days per month) associated with higher odds of adverse outcomes.
Actually just got on generic Cialis(Tadalafil) for its anti inflammatory effects throughout the cardiovascular system and brain. 5mg a day has had no negative side effects, other than some mild nose stuffiness the first couple days or so of adjusting to the new drug.
Given that Viagra stimulates blood vessels and blood flow, would one expect this would speed healing on the theory it increases blood flow to the needed area?
I wouldn’t count on it. It does have some benefit when it comes to increasing the blood flow but nothing that I have read to suggest that it helps with wound healing.
Yes Cialis (Tadalafil) has the same effect. Matt Kaeberlein has been considering taking Tadalafil for a while and said in a recent podcast that findings from a new study have convinced him to start - I think he said at a dose of 5 mg/day. Here’s the podcast, which is about 14 medications linked to lower death rates in humans:
My husband recently started taking Cialis for BPH, which we were happy about due to the longevity benefits. Also helps lower his BP.
Are you kidding me? 5mg per day doesn’t have that effect? Holly molly I did 5mg for five days only, and boy was I ever aroused 24/7. I stopped the 5mg and only doing 2.5mg but even that has a pretty HUGE effect. Don’t know when your husband started it, but if its been more than couple days, and you haven’t seen any “benefits” yet, you better check with your neighbor’s wife