I was seeking for specific compounds in Grapefruits to build a mixture to inhibit Cytochrom P450 3A4. But in short, its really complicated - Grapefruit is best.
“The available evidence indicates that, at commonly recommended doses, other selected herbs including Echinacea, Ginkgo biloba, garlic, goldenseal and milk thistle do not act as potent or moderate inhibitors or inducers of CYP enzymes.”
There are some effects, but in my opinion, not what we are looking for.
Here is an interessting study about the Coumarins found in various citrus fruits. After reading this, I thought my Citrus hystrix could be a good candidate for inhibiting CYP3A4. But in short: no.
findings: Naringin and 6’,7’-dihydroxybergamottin are not the major active ingredients.
Naringin itselfs is absolutly useless besides you want to sanitise something or maybe if you want to cure mouth sore.
they found out that Grapefruits have more Coumarins with fancy Furan-rings.
the newest one, seems like Grapefruit is the anwser: its the specific combination found in Grapefruits that inhibits CYP3A4.
If anyone is interessted in adulderating a mixture, this is what you are looking for.
Compounds are:
And even if it was in vitro:
is intressting to know. Search for: salvage pathway.
I am wondering if NMN, a nicotinamid derivate with 3 phosphate groups, could increase this process. But the salvage pathway isn’t about my intestinals and I am not a petri dish.
So I decided not to worry about it. I just keep calm and eat grapefruits.