There are at least 3 forms of vitamin B6 depending on your definition.
I can’t find pyridoxamine on Amazon, but they sell Pyridoxal 5-Phosphate form which is quite a bit more expensive than the common form Pyridoxine.
What are you thoughts on comparing pyridoxamine to the Pyridoxal 5-Phosphate form?
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Sure I don’t mind if you invite him to discuss this. I should tell you though that we have already discussed this somewhat on some Facebook groups and he is probably as tired of trying of defend my points as I am of being the “bad guy” here when I point out the flaws behind the product and it’s marketing. I think he is a well meaning scientist but I don’t agree with his conclusions of his research (like him thinking glycation reduction results in weight loss) nor the marketing of GLYLO.
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Good question.
To start with lets get one thing clear. Vitamin B6 exists in three forms, pyridoxine, pyridoxal and pyridoxamine. Then there are three additional variations which are these three forms each with a phosphate group attached, namely pyridoxine-5-phosphate (PNP), pyrixoxal-5-phosphate (PLP) and pyridoxamine-5-phosphate (PMP). So six forms in total.
Pyridoxine, pyridoxal and pyridoxamine are all converted into PLP, but PLP is the coenzymatically active form of vitamin B6 in the body that performs the vitamin functions of vitamin B6.
Now PLP is sometimes sold as a supplement and claimed to be superior to the other forms on the basis that it’s the coenzymatically active form and therefore it the most useful form. People are told it makes sense to take PLP directly and that it’s better than taking other forms because the other forms need to be converted into PLP. This is supposed to justify the higher price of PLP supplements. This is wrong! PLP cannot be taken up by cells without first being dephoshorrylated into pyridoxal, so taking PLP ends up being a waste of money since eventually it has to be converted into the cheaper pyridoxal before being absorbed. Once inside cells the pyridoxal is then converted back to PLP to be used by the cells.
So there you have it. Don’t waste money on PLP. Just stick with pyridoxine if you can’t find a source of pyridoxamine.
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This talk by Collin Ewald brings up the idea that degradation of the ECM is an independant hallmark if aging. And he think that chondroitin sulphate and Hyaluronic acid might be used to slow down the aging of the ECM.
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Chebulic acid from Terminalia chebula extract: “exhibiting 50-fold stronger breaking activity than with ALT-711, a well-known cross-link breaker.”
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I’ve been trying to find more info on Revel Pharma’s progress on the glucosepane breaker but it looks like they’ve put that on halt for now to focus on carboxymethyllysine. The CEO Aaron Cravens was at the Berlin Rejuvenation Summit recently and they are now focused on an enzyme for CML. I was under the impression that ALT-711 already breaks CML. It might be that an enzyme may not be able to break glucosepane entirely.
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I remember back in the late 1990s and early 2000s Alt-711 made a lot of news and press and looked very promising, but nothing ever came of it. Is it still being talked about… I haven’t followed it in a long time. I think it failed clinical studies…
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There has been other studies of it breaking cross links in rats, just not glucosepane. It’s not widely mentioned but I believe it could be useful. I did find a patent online for the glucosepane breaker enzyme that David Spiegel’s lab conducted in vitro, but nothing ever came about.
Patent
I don’t think ALT-711 is useless for longevity. It probably has minor benefits. The major problem with ALT-711 was that it doesn’t break glucosepane or any of the major cross-links in humans, so even even if it works at breaking the cross-links it targets, it’s only fixing a very small part of the problem. I think this was even more the case in humans than rodents because glucosepane is a major cross-link in humans but not necessarily the major one in mice and rats IIRC.
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I think its a funding issue for developing glucosepane breakers, there’s just not enough awareness out there about the importance of AGEs in longevity. Since it’s also not clear if an enzyme could even work, we need more people working on different avenues of breakers. If they had the money, I wonder how long it would take to actually find a suitable breaker and start trials.
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Revel Pharma updated their News page on their website with the link to their presentation at the Berlin Rejuvenation Summit 2024. Presentation Link
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