DeStrider's Rapamycin Protocol

[DeStrider]

It’s been a while since I’ve updated this thread.

I am now alternating between 3 mg Rapamycin+ GFJ and 2 mg Rapamycin+ GFJ every other week.

I am now taking 500 mg Metformin daily as well as 180 mg Bempedoic Acid.

We’ll see how my lipids and HBA1C are when next I test.

[scta123]

@DeStrider

500 mg Metformin

Why Metformin and not Acarbose and SLGT2i?

[DeStrider]

I am also still taking acarbose 100 mg before each meal. I just noted the changes I made to my base regimen.

I am not taking an SGLT2 drug yet as I hope the daily Metformin will push my HBA1C levels back into normal zones. If not, I may try one.

I have stopped taking Ezetimibe for now because I want to test the effects on cholesterol by Bempedoic Acid first. After my next blood test, I’ll add it back in and then see what effect it has.

Very good questions!

[DeStrider]

I decided I don’t want to mess around with ApoB or LDL and have added Ezetemibe back in. Everything is going smoothly. I will be doing a full body checkup at the end of March with a full blood panel.

My father will be taking Bempedoic Acid + Ezetemibe as well, so we’ll see how his lipid panel is impacted by them. My father had to stop taking Rapamycin due to a bacterial infection in his tooth which simply rages out of control when he takes Rapamycin so he is going to have a root canal before he begins Rapa again.

[DeStrider]

It’s been a while since I updated this, so here goes:

My father’s experience with Bempedoic Acid + Ezetimibe was a resounding success! His ApoB dropped about 40-50% from a high to a low risk. His inflammation (hs-CRP) also dropped from 1.2 to 0.57. I am now taking Bempedoic Acid + Ezetemibe as well. See below for more info:

Bempedoic Acid and Ezetemibe Results

I am over the moon! My 78 yo father just got his results from his blood work back. His ApoB went from 120 to 65 and his hsCRP went from 1.2 to 0.57. He hasn’t gotten his LDL, TG, TC and HDL results back, but so far I am ecstatic. This is after 1 month taking the drugs in one pill together. It’s the Indian Generic Brillo EZ from Jagdish Nikose. I’m taking it as well and will report my numbers when I get them. It feels like he bought an insurance policy against heart disease!!

I am currently alternating taking weekly 4 mg of Rapamycin + GFJ and 3 mg of Rapamycin + GFJ (14 mg - 10 mg Rapa equivalent). Currently, I am taking an off week as I have a bacterial infection and a mouth sore. Interestingly, the mouth sore caused shooting pain in the nearby molar, but since it has healed, the molar pain has gone away as well.

I have noticed that about every 3 weeks I develop a mouth sore, bacterial infection, or some other injury. I then stop taking Rapa for a week to allow my body to recover. I just finished a 3-day course of Azithromycin and Vitamin C to treat the bacterial infection (and as a mini-DAV experiment). It worked well and I will start taking Rapa again on Saturday.

I am still taking 500 mg of Metformin daily and Acarbose with my carb-heavy meals. I am having my body check at the hospital tomorrow so I should have new bloodwork results available in about 5-6 weeks. I’m really interested in seeing my new HBA1C and lipid panels!

[SilentWatcher]

@DeStrider, thank you for sharing your experience.

Are you monitoring your fasting glucose levels with a Continuous Glucose Monitor? I have observed a consistent and systematic effect on fasting glucose levels (100-120 mg/dL) for 6-7 days following the administration of rapamycin (2 mg with grapefruit; 3 mg with grapefruit introduces some sort of glucose volatility on top in my n=1 case). In response to this observation:

• I am introducing 800 mg of Metformin 1-2 days before and after taking rapamycin, as the effects of Metformin on glucose levels become noticeable after 3 days of intake.
• I have decided to cycle rapamycin every three weeks to maintain stable fasting glucose levels for at least two weeks.

Currently, I view this glucose intolerance as part of the therapeutic effects of the starvation-mimicking drug rapamycin. (Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to; Mikhail V. Blagosklonny)

Therefore, I strongly recommend monitoring fasting glucose levels around the time of rapamycin intake to observe personal responses and decide on a regimen.

[garym37]

Thanks so much for sharing all this information.

[DeStrider]

I have just received my blood work results. This was on my protocol plus 500 mg Metformin and 140 mg Bempedoic Acid and 10 mg of Ezetemibe.

LDL cholesterol - 66 mg/dl (Down from 122 mg/dl)
HDL cholesterol - 46 mg/dl (Down from 54 mg/dl)
Total Cholesterol - 123 mg/dl (Down from 194 mg/dl)
Triglycerides - 84.1 mg/dl (Down from 101 mg/dl)

HBA1C - 4.9% (Down from prediabetic 5.7%)

Based on my father’s and my results, Bempedoic Acid and Ezetemibe do what they’re supposed to with a 45-50% decrease in LDL and ApoB.

500 mg of Metformin also moved me out of prediabetes into a normal (optimal) zone.

Since Rapamycin raised both my HBA1C and LDL cholesterol, it seems that these two drugs do a great job of counteracting these bad side effects of Rapamycin.

This also probably explains why Metformin paired with Rapamycin helped mice live longer in the ITP trials. Since mice don’t die of heart attacks, but humans do, I’d wager we need to treat high cholesterol to optimize our lifespan further.

Summary: Rapamycin+Bempedoic Acid+Ezetemibe+Metformin is a winning combination N=2